Thursday, January 12, 2017
Alzheimer Treatment Allows Dentin Regrowth
Motherboard reports: [edited]
Researchers at King’s College released a study stating they’ve discovered a medicine that can prompt teeth to regrow over cavities or injuries.
Researchers realized that an experimental Alzheimer’s drug called Tideglusib had the side effect of encouraging dentin growth, which is the bony part of the tooth made of calcified tissue. It makes up most of the tooth, just above the pulp but under the hard enamel.
Tideglusib, used in clinical trials as a neurological drug as a way to encourage brain cell growth, encouraged the tooth to generate more stem cells and grow dentin over the exposed area, according to the report.
Normally, a tooth only grows a tiny layer of dentin over an injury — not nearly enough to save a tooth from needing to be drilled or removed to prevent infection. But when Tideglusib is applied to the injured spot on the tooth, it blocks the enzyme that usually stops dentin growth, glycogen synthase kinase (GSK-3), and the whole spot heals up by itself.